I do not know how many times I said to myself that I should write a post about this problem

Sometimes when trying to log on to an Exchange 2010 server, you receive the following error message:

The User Profile Service service failed the logon
User Profile Can not Be Loaded

the problem is access to a file in the user’s profile. This is copied from the default profile so it does not help to remove the profile and create a new one.

The file is:

C: Users Default AppData Local Microsoft Exchange Server V14 CmdletSqmData3700_100.sqm

The solution is change the permissions on the files in the default profile to Everyone – Full Control

Edit: moved around some text, then I do not korrläst properly. Thanks Anders A