1. Click Start | Run and open Regedit32.exe
2. If the setting has been modified previously**, browse to HKEY_CURRENT_USERSOFTWAREVERITASDLOClientDefaultMediaServer
3. If the setting has not been modified previously, browse to HKEY_LOCAL_MACHINESOFTWAREVERITASDLOClientDefaultMediaServer
Note: The current user key will override the Local Machine Key settings.
4. Right-click on DefaultMediaServer and select Modify
5. Type the new DLO media server name in the Value datafield
6. Close the registry editor
7. Restart the desktop computer to move the client storage to the new DLO media server

Source: Symantec Knowledge Base